In-vitro Tewameter® VT 310

The Invitro Tewameter® VT 310 is a specialized TEWL measurement probe designed for in vitro testing on Franz cells. It offers the proven advantages of the Courage + Khazaka Tewameter® open-chamber measurement principle, while being specially shaped to sit directly on the Franz cell membrane without the need for additional adapters.  

The VT 310 can replace the upper donor chamber of a Franz cell, allowing TEWL to be measured in g/h/m², the internationally recognized unit for transepidermal water loss. This makes the system useful for studying skin permeability, dermal absorption, barrier function, and safety or efficacy testing before moving to in vivo studies.  

For specific protocols, the probe can also be used with a high-quality Teflon centerpiece placed between the probe and the receptor chamber. This setup is useful when preparations need to be applied to the membrane during measurement, although the resulting TEWL values should be interpreted relatively rather than as absolute values.  

The Invitro Tewameter® VT 310 supports continuous long-term measurements, and up to 10 probes can be used simultaneously, making it suitable for comparative studies and time-dependent testing. It can be connected to compatible MPA systems, allowing TEWL values, averages, standard deviations, temperature, and relative humidity data to be recorded and displayed during measurement.