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ReleGO™ & REVex™ Microfluidic Technology
Advanced Skin-on-Chip Platforms for Dynamic In Vitro and Ex Vivo Skin Testing
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Overview
The provided sources detail the innovative 4D organ-on-a-chip technology developed by REVIVO BioSystems to modernize in vitro testing. This microfluidic platform, consisting of the ReleGO™ automated sampler and REVex™ chips, simulates natural human physiology by mimicking blood flow and nutrient transport. By utilizing human tissue explants and synthetic models, the system offers a more accurate alternative to traditional methods while remaining 100% animal cruelty-free. Businesses in the pharmaceutical and cosmetic sectors benefit from significant cost and labor savings during safety and efficacy evaluations. Ultimately, these advanced tools empower researchers to validate products more efficiently through high-precision data and realistic biological simulations.
REVIVO BioSystems
4D HUMAN TISSUE TESTING PLATFORM
Complete solutions
ReleGO™
FULLY AUTOMATED & PROGRAMMABLEFRACTION COLLECTOR
REVex™
Tissue-ON-CHIPCOMPATIBLE WITH HUMAN EXPLANTS, COMMERCIAL RECONSTRUCTED SKIN SIMULANTS, SYNTHETIC MEMBRANES AND OTHER TISSUES
Innovative in microfluidic technology expert in 3D human tissue model
Features
Dynamic skin-on-chip testing platform
ReleGO™ creates a controlled microfluidic environment that supports more realistic in vitro and ex vivo skin testing compared with static models.
Automated sample collection
The platform can collect receptor fluid over time, supporting kinetic studies such as permeation, absorption, and release profiling.
Perfusion-based culture conditions
The system continuously circulates culture medium, helping mimic physiological flow and support longer-term skin tissue viability.
Reduced reliance on animal testing
ReleGO™ supports non-animal testing approaches for cosmetic, pharmaceutical, and dermatological research.
Suitable for reconstructed and ex vivo skin models
ReleGO™ can be used with advanced skin models to study product effects, tissue response, permeation, irritation, and biological activity.
Flexible applications for skin research
Suitable for studies in skin permeation, wound healing, anti-aging, safety testing, efficacy evaluation, and biomarker analysis.
Technology
The ReleGO and REVex platform is a state-of-the-art 4D microfluidics technology designed to provide a highly representative in vivo-like environment for human tissue testing.
ReleGO serves as a fully automated, programmable fraction collector that integrates precise temperature regulation and fluidic handling to mimic the dynamic function of human blood flow.
Mounted within this system are REVex chips—specialized microfluidic devices that house tissue samples and provide a continuous supply of nutrients and reagents through microscopic channels.
This “4D” technology introduces time as a critical dimension, enabling the long-term maintenance of tissues for durations ranging from several hours up to 21 days, which allows for complex kinetic studies that are impossible with traditional static models.
Comparison of traditional technology and REVIVO Biosystems’s platform
| ReleGO™ Platform | Automated sampler apparatus for vertical diffusion cells | Automated sampler apparatus for flow-through cells | Manual Vertical Franz Diffusion Cell Apparatus | |
|---|---|---|---|---|
| Mimic natural conditions | ✓ | ✕ | ✕ | ✕ |
| Cost factor | 1 | 5 | 2 | 1–2 |
| Dimensions factor | 1 | 6 | 3 | 3 |
| Weight factor | 1 | 5–6 | 3–4 | 3 |
| Diffusion Device | REVex Chip | Vertical diffusion cell | Flow-through cell | Vertical diffusion cell |
| Automated sampling | ✓ | ✓ | ✓ | ✕ |
| Tissue samples per run | 12 | 12 | 7 | 9 |
| Size of skin specimen per replicate | 0.5 cm² | 2–4 cm² | 2–4 cm² | 2–4 cm² |
| Manhours for a 24h study | 1h | 9h | 9h | >18h |
| Long-term maintenance of tissue models | ✓ | ✕ | ✕ | ✕ |
| Sampled columns are collected in | 96-well plates | Cuvettes | Customized cuvettes | Cuvettes |
| Automated cleaning | ✓ | ✕ | ✕ | ✕ |
Looking for a guideline for your own application with ReleGo microfluidic system?
ReleGO™ & REVex™ Applications
Dynamic 4D microfluidics for human-relevant skin testing
Skin Permeation & Absorption
Evaluate how active ingredients,drugs, or cosmetic compoundspenetrate through skin tissue overtime.
Long-Term Tissue Culture
Maintain skin tissues orreconstructed models over extendedperiods for kinetic andtime-dependent evaluations.
IVRT & IVPT Research
Support in vitro release andpermeation workflows withautomated sample collection andcontrolled perfusion.
Wound Healing Studies
Assess tissue recovery, repairmechanisms, biomarker release, andtreatment response using advancedskin models.
Anti-Aging & Efficacy Testing
Study collagen response, barrierfunction, inflammation, hydrationsupport, and long-term skin tissuebehavior.
Skin Safety & Irritation Testing
Evaluate irritation, toxicity,inflammation, and adverse tissuereactions to ingredients andformulations.Prepared for
Biomarker & Secretome Analysis
Collect time-based samples foranalysis of cytokines, proteins,inflammatory markers, and otherbiological signals.
Topical Formulation Testing
Test creams, gels, serums, patches,transdermal products, anddermatological formulations underdynamic flow conditions.
Cosmetic, Pharma & Dermatology R&D
Suitable for product development,efficacy testing, claim support,preclinical screening, and advancedhuman-relevant skin studies.
Animal-Free Alternative Testing
Support cruelty-free research usinghuman skin, engineered skin models,synthetic membranes, or REVskintissue.
FAQs
What is the difference between ReleGO™ and REVex™?
ReleGO™ is the automated microfluidic control and fraction collection system, while REVex™ refers to the specialized microfluidic chips that hold the skin tissue or membrane. Together, they create a dynamic skin-on-chip platform for advanced in vitro and ex vivo skin testing.
What types of skin models can be used with ReleGO™ and REVex™?
The platform can be used with different models, including native human skin, ex vivo skin samples, synthetic membranes, and engineered animal-free skin models such as REVskin™, depending on the study design.
Why is the platform called “4D microfluidics”?
It is called 4D because it adds time as a key testing dimension. The system can maintain tissues under dynamic flow conditions for extended periods, allowing researchers to study biological responses, permeation profiles, and biomarker release over time.
How does ReleGO™ & REVex™ differ from traditional Franz cells?
Traditional Franz cells are mainly static diffusion systems, while ReleGO™ & REVex™ use dynamic microfluidic perfusion. This helps mimic physiological flow, supports longer tissue viability, and enables time-based sample collection for more advanced kinetic studies.
More questions about Vitro-Skin?
Please fill up the form to download complete FAQ pdf
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