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Overview
VITRO-SKIN® is a synthetic, non-biological skin substrate designed to mimic important surface properties of human skin for in vitro testing. It is widely used in cosmetic, personal care, pharmaceutical, and medical device research as a standardized alternative substrate when testing directly on human skin is not practical during early-stage development.
VITRO-SKIN® is formulated to reproduce key characteristics of human skin surface, including topography, pH, critical surface tension, chemical reactivity, and ionic strength. This makes it suitable for evaluating how formulations spread, deposit, adhere, dry, resist water, or interact with a skin-like surface.
Because each sheet offers consistent surface properties, testing on VITRO-SKIN® can provide more reproducible results than testing on human skin, where natural variability between subjects can affect results. It is used in a broad range of methods, including in vitro SPF/UVA testing, sunscreen water resistance, skin deposition studies, adhesive testing, antimicrobial and antiviral testing, cosmetic formulation development, and product performance screening.
For R&D teams, VITRO-SKIN® provides a practical and economical platform to support method development, formulation comparison, performance evaluation, and claim substantiation before moving to more advanced clinical or human-based studies.
Successfully applied in a broad range of in vitro methods
VITRO-SKIN® is currently used by over 175 leading companies worldwide
An ideal substrate for all of your Life Science Testing and Cosmetic formulation needs
GLOBALLY APPROVED BY WORLS LEADER ORGANIZATION
Features
Synthetic, non-biological skin model designed for rapid and predictive in vitro testing.
Mimics the surface properties of human skin, including topography, pH, critical surface tension, chemical reactivity, and ionic strength.
Contains optimized protein and lipid components to better reproduce human skin-like behavior.
Easy to use for a wide range of life science, cosmetic, personal care, and R&D applications.
Long shelf life, making it practical for routine laboratory testing.
Widely recognized in research and product development, referenced in approximately 100 patents.
Compatible with multiple testing methods, including permeation studies, SPF screening, adhesion testing, microbiome studies, antimicrobial testing, and medical device testing.
Application
Vitro-Skin® is used as a reliable synthetic skin substrate for evaluating how formulations interact with the skin surface under controlled laboratory conditions. It is suitable for cosmetic, personal care, pharmaceutical, and medical device development where consistent, reproducible testing is required.
Permeation studies
Anti-Bacterial testing
Anti-Viral testing
Microbiome studies
Anti-Fungal testing
R&D testing of raw materials for personal care
color comparisons
In-Vitro SPF screening
Adhesion testing
Medical Device testing
Bandage testing
Durability testing
Waterproof test for UV protection effect
test make up removal properties of facial cleansers
Evaluation of skin care products
Tissue Substitute
Malodor Reduction
Coefficient Of Friction Test
Deposition Studies
Cosmetic development using Haze meter
lipstick pay-out, wear and durability evaluation
Looking for a guideline for your own application with Vitro-Skin?
starter kit
The VITRO-SKIN® Starter Kit includes two VITRO-SKIN® sheets and a Hydration Chamber for proper sample preparation before testing.
VITRO-SKIN® Starter Kit includes:
1x IMS in vitro SPF/UVA testing protocol
2x 22 cm x 27 cm (8.5″ x 10.5″) sheets of VITRO-SKIN®
4x 6 cm x 6 cm sample holders
2x 35 mm reference holders
112x latex finger cots
1x plastic hydration chamber with two mesh shelves and a spacer
1x plastic covered foam block (to simulate the flexibility of the human dermis)
Patents Referencing VITRO-SKIN® Substrate
Hybrid Material of Crosslinked Microgel Particles Dispersed in an Adhesive (Avery Dennison Corporation)
Gel Wipe Composition Comprising a Superabsorbent Gel Fiber (Johnson & Johnson Consumer Inc.)
Emulsion Compositions and Applications Therefor (Momentive Performance Materials Inc.)
Oral Care Method And Kit (3M Innovative Properties Company)
Oral Care Compositions (Colgate-Palmolive Company)
Hair Removal Method And Hair Removal Kit (The Procter & Gamble Company)
Ask for more...
FAQs
What is VITRO-SKIN®?
VITRO-SKIN® is a collagen based synthetic skin substrate, formulated and
produced to mimic human skin. The topography, pH and surface tension are
very similar to human skin, so it is the ideal substrate for in-vitro testing
where human skin is required.
How do I use VITRO-SKIN®?
VITRO-SKIN® is typically hydrated in a Hydration Chamber (part of the Vitro-Skin Starter Kit) prior to use, however some applications may not require hydration. The applications of this material are extremely diverse, so methods will vary depending on use application.
What testing can be performed using VITRO-SKIN®?
VITRO-SKIN® is used in a wide variety of industries where testing of products on skin is necessary. Some of the areas where Vitro-Skin is currentlybeing utilized include personal care, OTC products, chemical industry testing, Veterinary applications, disinfectants, Microbiome studies,
anti-viral and anti-bacterial studies, adhesives markets, medical devices, dermal penetration/absorption studies, skin moisturization studies, malodor studies, coefficient of friction studies, waterproof/water resistance studies, soft focus studies, etc.
More questions about Vitro-Skin?
Please fill up the form to download complete FAQ pdf
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